Modular Artificial Cupredoxins

Modular design of artificial transcription factors.

Eukaryotic transcription factors are composed of interchangeable modules. This has led to the design of a wide variety of modular artificial transcription factors (ATFs) that can stimulate or inhibit the expression of targeted genes. The ability to regulate the expression of any targeted gene using a 'programmable' ATF offers a powerful tool for functional genomics and bears tremendous promise ...

The evolution of modular artificial neural networks

Modular Modeling of an Artificial Organ System

A relevant research field is the development of closed-loop combinations of neural tissue and robotics, such as animats and hybrots [4]. As such, a proposed framework for a simple, modular synthetic organism will be evaluated. A closed-loop circulatory system would be used to sustain a “brain” via homeostatic maintenance of a balance of essential nutrients and waste removal. The modular “brains...

Modular construction of a functional artificial epothilone polyketide pathway.

Natural products of microbial origin continue to be an important source of pharmaceuticals and agrochemicals exhibiting potent activities and often novel modes of action. Due to their inherent structural complexity chemical synthesis is often hardly possible, leaving fermentation as the only viable production route. In addition, the pharmaceutical properties of natural products often need to be...

Estimation of Missing Precipitation Records Using Modular Artificial Neural Networks

Estimation of missing precipitation records is one of the important tasks in hydrological study. The completeness of precipitation data leads to more accurate results from the hydrological models. This study proposes the use of modular artificial neural networks to estimate missing monthly rainfall data in the northeast region of Thailand. The simultaneous rainfall data from neighboring control...